Istituto degli Endotipi in Oncologia, Metabolismo e Immunologia
“G. Salvatore”
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Institute of Endotypes in Oncology, Metabolism
and Immunology “G. Salvatore” – IEOMI
On the basis of recent activites and ongoing projects, the
scientific areas are based on the characterization of molecular and cellular
mechanisms involved in the development of different pathologies. This
approach is defined as the study of endotypes, intended as the correlation and
integration between genetic-epigenetic issues and environmental/phenotypic
aspects mainly described from non-coding RNA profiles, as well as lipid,
carbohydrate and protein profiles (including post-translational, PTMs).The general objectives include the identification of
pathology markers, both for diagnostics and monitoring and also for target
therapies, integrating fundamental and applied research.
These activities will increasingly have to be
developed in a systems vision (Systems Biology/Medicine) to be able to strive
for a more personalized medicine.
Based on the expertise acquired and the need for their
evolution, the scientific areas of intervention concern the study of:
Oncology - including the characterization in the
carcinogenesis of proliferation, differentiation and cell death, of subcellular
structures with the development of new drugs, biosensors and vectors.
Metabolism –
including the characterization of molecular and cellular mechanisms that have a
role in the development of metabolic diseases and the relationships between
lifestyles, obesity, development of diabetes and associated complications.
Immunologia - including the characterization of molecular/cellular mechanisms underlying
immune-mediated disorders and the role of the immune system in disease.
The general areas described above, although
diversified by origin and environmental context, are interconnected with each other and shared by pathogenetic and metabolic
alterations.
An important part of the activity of the Institute
regards the infrastructures BBMRI, for the collection and distribution of
biological material and Eurobioimaging, specialized
in the various aspects of microscopy and live imaging. The combination of
high resolution images of cellular structures with omic analysis, also supported by the collaboration
with IR Elixir, will allow to increase the precision of molecular-cellular
profiles (Precision Medicine). Furthermore, the participation in BBMRI
will permit the Institute to integrate its cellular models (2D and 3D) and
animals, with human specimens (real life).
The two IR will place the Institute in a
favorable competitive position, the must be exploited and developed in the near future.
Finally, activities already underway in the
Institute will continue be developed and have made public through Communication
to the population of ongoing research, the Dissemination of Information
of the results and their Use (Exploitation) in the scientific
community and territory.